The thyroid gland is located either side of around a dog’s larynx and its function is to produce a hormone called thyroxine, which regulates the metabolism rate of most tissues in the body. A thyroxine deficiency due to an affected thyroid gland causes cell function to decrease, impacting on several of the body’s organ systems. Hypothyroidism affects approximately 0.2% of all dogs. Signs develop gradually and spread widely.